CHROMODOMAIN AND BROMODOMAIN
Chromodomain A chromodomain is a protein structural domain of around 40-50 amino acid residues that is frequently found in proteins involved in chromatin remodelling and manipulation. Additionally, it is referred to as a chromatin organisation modifier. It was discovered for the first time in Drosophila moderators of variegation.The chromodomains remodel chromatin into the condensed shape of heterochromatin, a cytologically observable state of suppressed gene expression.Both plants and animals have a high degree of conservation within the domain.It is encoded by a huge number of proteins found in a wide variety of genomes.Certain genes with chromodomains have several alternative splicing isoforms that lack the chromodomain altogether.Chromodomain-containing proteins are involved in many aspects of gene regulation in mammals, including chromatin remodelling and the development of heterochromatin areas. Additionally, proteins with chromodomains bind methylated histones and are incl...
